发明名称 |
SYSTEM FOR CONTROLLED RELEASE OF AN ACTIVE PRINCIPLE AND METHOD FOR PREPARATION |
摘要 |
A system for controlled release of an active principle, includes at least (a) a degradable polymer matrix which produces acid compounds and (b) at least one acid-sensitive complex of an active principle having at least one electrostatic charge and a complexing polyelectrolyte partner of opposite charge which complexes with the active principle. A method for preparation of such a system is described. The release of the active principle (7P) is prolonged over 18 days (ternary system PMLA/7P/PLAGA) in comparison to binary systems (7P/PLAGA) and (PMLA/7P).
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申请公布号 |
US2010260848(A1) |
申请公布日期 |
2010.10.14 |
申请号 |
US20080669252 |
申请日期 |
2008.07.18 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE DE MONTPELLIER 1 |
发明人 |
VERT MICHEL;LECLERCQ LAURENT;BOUSTTA MAHFOUD |
分类号 |
A61K9/00;A61K38/08;A61P29/00;A61P35/00 |
主分类号 |
A61K9/00 |
代理机构 |
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