发明名称 |
TRIAZOLE-BASED AMINOGLYCOSIDE-PEPTIDE CONJUGATES AND METHODS OF USE |
摘要 |
Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycoside antibiotic may exhibit antimicrobial activities against Gram-positive and/or Gram-negative strains and display significantly enhanced activity against multi-drug resistant MRSA and MRSE when compared to their unconjugated aminoglycoside antibiotic counterparts.
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申请公布号 |
US2010261639(A1) |
申请公布日期 |
2010.10.14 |
申请号 |
US20080602318 |
申请日期 |
2008.05.28 |
申请人 |
UNIVERSITY OF MANITOBA |
发明人 |
SCHWEIZER FRANK;ZHANEL GEORGE G.;BERA SMRITILEKHA |
分类号 |
A61K38/14;A61P31/04;C07H1/00;C07K9/00 |
主分类号 |
A61K38/14 |
代理机构 |
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