摘要 |
<p>The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The trivalent, bispecific antibodies of the invention comprise a full length antibody specifically binding to a first antigen and consisting of two antibody heavy chains and two antibody light chains and a VH domain fused to the C-terminus of one of said heavy chains and a VL domain fused to the C-terminus of the other said heavy chains, wherein said VH domain and said VL domain together form an antigen-binding site specifically binding to a second antigen.</p> |
申请人 |
ROCHE GLYCART AG;BRINKMANN, ULRICH;CROASDALE, REBECCA;HOFFMANN, EIKE;KLEIN, CHRISTIAN;MOESSNER, EKKEHARD;SCHANZER, JUERGEN MICHAEL;UMANA, PABLO |
发明人 |
BRINKMANN, ULRICH;CROASDALE, REBECCA;HOFFMANN, EIKE;KLEIN, CHRISTIAN;MOESSNER, EKKEHARD;SCHANZER, JUERGEN MICHAEL;UMANA, PABLO |