| 发明名称 |
FC VARIANTS WITH ALTERED BINDING TO FCRN |
| 摘要 |
<p>The present application relates toa variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.</p> |
| 申请公布号 |
EP2235059(A1) |
申请公布日期 |
2010.10.06 |
| 申请号 |
EP20080866130 |
申请日期 |
2008.12.22 |
| 申请人 |
XENCOR, INC. |
发明人 |
CHAMBERLAIN, AARON;DAHIYAT, BASSIL;DESJARLAIS, JOHN RUDOLPH;KARKI, SHER BAHADUR;LAZAR, GREGORY ALAN |
| 分类号 |
C07K16/22;C07K16/24;C07K16/28 |
主分类号 |
C07K16/22 |
| 代理机构 |
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