TREATING SURFACES TO ENHANCE BIO-COMPATIBILITY

摘要

Described is a method of treating an article having at its surface oxide or hydroxide moieties, as well as the resulting treated article. The method includes priming the surface of the article by contact with an alkoxysilane in an aprotic organic solvent in the presence of an acid catalyst so that the alkoxysilane reacts with the oxide or hydroxide moieties of the surface. This yields a primed surface. A polymer is then reacted with one or more amino, hydroxyl, carboxylic acid and/or acid anhydride groups on the surface to covalently couple the polymer to the primed surface via the alkoxysilane. The reaction with the polymer is not a free-radical reaction.