发明名称 |
PROCESS FOR THE PREPARATION OF ALOGLIPTIN |
摘要 |
<p>The present invention is based on the discovery of a process for preparing pyrimidin- dione compounds, especially alogliptin and its derivatives, which comprises the reaction of a urea derivative of formula (VIII) with a malonic acid or its derivatives to form intermediates of formulae (VII) or (VII-A), which are subsequently converted to a compound of formula (II) upon introduction of a leaving group X. Compound (II) then reacts with an amine to form compound (I), which is optionally converted to its salts of formula (IV).</p> |
申请公布号 |
WO2010109468(A1) |
申请公布日期 |
2010.09.30 |
申请号 |
WO2010IL00260 |
申请日期 |
2010.03.25 |
申请人 |
MAPI PHARMA HK LIMITED;MAROM, EHUD;MIZHIRITSKII, MICHAEL;RUBNOV, SHAI |
发明人 |
MAROM, EHUD;MIZHIRITSKII, MICHAEL;RUBNOV, SHAI |
分类号 |
A01N43/54 |
主分类号 |
A01N43/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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