发明名称 |
RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
摘要 |
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of NGFß gene expression and/or activity, and/or modulate a NGFß gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against NGFß gene expression. |
申请公布号 |
WO2010111468(A2) |
申请公布日期 |
2010.09.30 |
申请号 |
WO2010US28629 |
申请日期 |
2010.03.25 |
申请人 |
MERCK SHARP & DOHME CORP.;STRAPPS, WALTER;JADHAV, VASANT;PICKERING, VICTORIA |
发明人 |
STRAPPS, WALTER;JADHAV, VASANT;PICKERING, VICTORIA |
分类号 |
A61K31/712;A61K31/713;A61P11/00;C12N15/113 |
主分类号 |
A61K31/712 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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