ANTIFOLATE COMPOUNDS FOR THE TREATMENT OF MELANOMA

摘要

This invention relates to compounds of the formula X) or XI) (X) (XI) wherein: each—R1,—R2 and—R3 is independently -Q1,—OH or—H, where at least one of—R1,—R2 and—R3 is not—H or—OH; each—R4 and—R5 is independently -Q2 or—H; each -Q1 is independently selected from:—F,—Cl,—RA,—ORA,—SH,—SRA, where each—RA is independently selected from methyl and ethyl, which may substituted by one or more fluoro or chloro groups; and each -Q2 is selected from:—F,—Cl,—RB,—ORB,—SH,—SRB, where each—RB is independently selected from methyl and ethyl, which may substituted by one or more fluoro or chloro groups; which are useful in the treatment of melanoma.