NON-INVASIVE DIAGNOSTIC IMAGING TECHNOLOGY FOR MITOCHONDRIA USING RADIOLABELED LIPOPHILIC SALTS

摘要

The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with ¹⁸F for non-invasive assessment of DeltaPsim, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.