SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION

摘要

The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-ß/BMP signaling pathway. In some aspects, the invention relates, to oligonucleotides comprising a CAGRN-motif that modulate expression of miRNAs that are regulated by TGF-ß/BMP signaling pathway. The invention, in some aspects, relates to composition and methods useful for inhibiting microRNA processing. In some aspects, the invention relates to composition and methods for treating TGF-Beta/BMP mediated disorders.