发明名称 |
BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE INHIBITORS |
摘要 |
The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell expresses certain sensitivity or resistance biomarkers, or genomic classifiers. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate this methodology are also provided.
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申请公布号 |
US2010240665(A1) |
申请公布日期 |
2010.09.23 |
申请号 |
US20090582013 |
申请日期 |
2009.10.20 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
ECKHARDT SUE GAIL;PITTS TODD MICHAEL;TAN AIK CHOON |
分类号 |
A61K31/4985;C12Q1/00;C12Q1/32;C12Q1/42;C12Q1/48;C12Q1/68 |
主分类号 |
A61K31/4985 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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