| 摘要 |
Peptide constructs, which are useful in the treatment or prevention of autoimmune diseases, specifically rheumatoid arthritis (RA), wherein the peptide constructs have the formula PI-X-P2 where Pl is a peptide associated with autoimmune disease, allergy, asthma, host-versus-graft rejection, myocarditis, diabetes, and immune-mediated disease, which binds to an antigen receptor on a set or subset of T cells; P2 is a peptide which will cause a Th2 directed immune response by the set or subset of T cells to which the peptide Pl is attached or which will bind to a T cell receptor which will cause the set or subset of T cells to which the peptide Pl is attached to initiate, but not complete, an immune response causing the set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding Pl and P2. |
