| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel salt forms of a base, where the base is (2-pyrrolidin-1-yl-ethyl)-amide 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylc acid, and where the salt form is selected from a group consisting of citric and phosphate salts, and to their solvates and polymorphs. The invention also relates to a polymorph (form 1) of a phosphate salt in claim 2, to a pharmaceutical composition, to a method of modifying catalytic activity of protein kinase, to a method of preventing or treating protein kinase related disorders in the body, to a method of obtaining crystals of the phosphate salt of the base in claim 1, to a method of obtaining polymorphs of the phosphate salt in claim 2, to a method of obtaining crystals of the citric salt of the base in claim 1, as well as to use of the phosphate salt in claim 2 and citric salt in claim 5. ^ EFFECT: obtaining new biologically active compounds which modulate protein kinase activity. ^ 17 cl, 8 ex, 8 tbl, 6 dwg |
