发明名称 |
PROCEDIMENTO PER LA PREPARAZIONE DELLA 6-(7-((1-AMMINOCICLOPROPIL)METOSSI)-6-METOSSICHINOLIN-4-ILOSSI)-N-METIL-1-NAFTAMMIDE E SUOI INTERMEDI DI SINTESI |
摘要 |
A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described. |
申请公布号 |
ITMI20090397(A1) |
申请公布日期 |
2010.09.17 |
申请号 |
IT2009MI00397 |
申请日期 |
2009.03.16 |
申请人 |
EOS ETHICAL ONCOLOGY SCIENCE SPA IN FORMA ABBREVIA |
发明人 |
LIVI VALERIA;SPINELLI SILVANO |
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