发明名称 |
Recombinant BCG Strains with Enhanced Ability to Escape the Endosome |
摘要 |
Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains.
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申请公布号 |
US2010233213(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
US20090650606 |
申请日期 |
2009.12.31 |
申请人 |
SUN RONGGAI;HONE DAVID MICHAEL;SADOFF JERALD C |
发明人 |
SUN RONGGAI;HONE DAVID MICHAEL;SADOFF JERALD C. |
分类号 |
A61K39/04;A61P31/04;C12N1/21;C12N15/74 |
主分类号 |
A61K39/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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