发明名称 |
ANTIBACTERIAL ANTISENSE OLIGONUCLEOTIDE AND METHOD |
摘要 |
A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3′ or 5′ end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications.
|
申请公布号 |
US2010234281(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
US20100723413 |
申请日期 |
2010.03.12 |
申请人 |
WELLER DWIGHT D;GELLER BRUCE L;IVERSEN PATRICK L;TILLEY LUCAS D;HASSINGER JED N |
发明人 |
WELLER DWIGHT D.;GELLER BRUCE L.;IVERSEN PATRICK L.;TILLEY LUCAS D.;HASSINGER JED N. |
分类号 |
A61K38/16;A61P31/04;C07K9/00 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|