| 摘要 |
In some aspects, the invention provides methods and compositions including HTm4, an HTm4 activator, and/or an HTm4 variant to potentiate a KAP phosphatase activity and or inhibit a CDK2 kinase activity. In some embodiments, a functional C-terminal fragment of HTm4 is provided. In other aspects, the invention provides methods and compositions including an HTm4 inhibitor to inactivate or decrease the activation of a KAP phospatase activity and/or activate or relieve the inhibition on a CDK2 kinase activity. Certain aspects of the invention relate to therapeutic compositions and methods for either inhibiting or promoting cell proliferation.
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