he present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
申请公布号
CA2753975(A1)
申请公布日期
2010.09.10
申请号
CA20102753975
申请日期
2010.03.02
申请人
ALNYLAM PHARMACEUTICALS, INC.
发明人
MANOHARAN, MUTHIAH;RAJEEV, KALLANTHOTTATHIL G.;KELIN, ALEXANDER V.;TAKKELLAPATI, SUDHAKAR RAO;MATSUDA, SHIGEO