BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNF-alpha INHIBITORS IN AUTOIMMUNE DISORDERS

摘要

The invention provides methods for predicting responsiveness to TNF± inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of responsiveness to TNF± inhibitors. A preferred biomarker of the invention is GD11c. The methods can further comprise selecting a treatment regimen with a TNF± inhibitor in an autoimmune disorder subject based upon expression of the biomarker(s) in the subject. The methods can further comprise administering a TNF± inhibitor to the subject according to the selected treatment regimen. Kits that include means for measuring expression of one or more biomarkers that are predictive of responsiveness to TNF± inhibitors for an autoimmune disorder are also provided.; Methods of preparing and using databases, and computer program products therefore, for selecting an autoimmune disorder subject for treatment with a TNF± inhibitor are also provided.