发明名称 Massive parallel method for decoding DNA and RNA
摘要 This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
申请公布号 US7790869(B2) 申请公布日期 2010.09.07
申请号 US20070810509 申请日期 2007.06.05
申请人 THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 发明人 JU JINGYUE;LI ZENGMIN;EDWARDS JOHN ROBERT;ITAGAKI YASUHIRO
分类号 C07H21/04;G01N33/53;C07B61/00;C07H19/04;C07H19/10;C07H19/20;C07H21/00;C12N15/09;C12Q1/68;G01N37/00 主分类号 C07H21/04
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