| 摘要 |
PROBLEM TO BE SOLVED: To provide a crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist. SOLUTION: A compound 2 which is the crystalline polymorph of the bisulfate salt can be obtained from a thrombin receptor antagonist compound 1 according to a process represented by formula (A). The compound 2 has higher stability than that of the compound 1. The compound can be used as a pharmaceutical composition for treating thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, myocardial infarction, glomerulonephropathy, thrombotic stroke, thromboembolic cerebral stroke, peripheral vascular disease, inflammatory lesion, cerebral ischemia or cancer. COPYRIGHT: (C)2010,JPO&INPIT
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