METHOD FOR PREPARATION OF NANOSTRUCTURED COMPLEX OF HYDROPHOBIC DRUG

摘要

PURPOSE: A method for preparing an insoluble drug nanocomplex is provided to enhance manufacture yield of the insoluble drug nanocomplex. CONSTITUTION: A method for preparing an insoluble drug nanocomplex comprises: a step of dissolving insoluble drug in a solvent containing surfactant; a step of adding apolipoprotein in the solution; a step of heating the solution; and a step of removing surfactant and solvent from the solution. The insoluble drug is dissolved with phospholipid. The phospholipid is phosphatidylcholine. The insoluble drug is coenzyme Q10, ursodeoxycholic acid, ilaprazole, paclitaxel or imatinib mesylate. The surfactant is cholic acid or salt thereof. The apolipoprotein is apolipotprotein A-I.