| 摘要 |
The invention relates to biopharmacology, preparative biochemistry and medicine, in particular to an agent which is based on a tuberculous complex produced by a microorganism and which can be used for tuberculosis prevention, treatment and diagnosis. The recombinant 2-9XL Acinetobacter johnsonii strain, which is harmless for man, animal and environment, comprises, in the composition of the chromosome thereof, the fragment(s) of a chromosomal DNA M. tuberculosis H37 Rv, which makes it possible to simultaneously synthesise several proteins for forming a stable species-specific tuberculous glycoprotein complex in the outer membrane and capsular substance of a bacterium. Ease of use of the recombinant 2-9XL strain, the use of standard media, the stability of the species-specific tuberculous complex synthesis, the cost-effective and safe practice for releasing and purifying the tuberculous complex render said microorganism a potential producer of the agent exhibiting properties to form the T- and B-cellular immunity against an M. tuberculosis originator. |
