Methods of inducing terminal differentiation using suberoylanilide hydroxamic acid (SAHA)

摘要

Disclosed is a crystalline form of suberoylanilide hydroxamic acid (SAHA) obtained by recrystallizing a crude preparation of SHA from a mixture of methanol and water. Also disclosed is a crystalline form of SAHA obtained by reacting suberic acid with aniline to obtain suberanilic acid, reacting the suberanilic acid with methanol to form methyl suberanilate, reacting the methyl suberanilate with hydroxylamine hydrochloride to form crude SAHA, and recrystallizing the crude SAHA from a mixture of methanol and water. (62) Divided Out of 550185