发明名称 NOVEL CHROMOPHORIC SILYL PROTECTING GROUPS AND THEIR USE IN THE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES
摘要 The present invention provides compounds of the formula (I): C-Q-O—Si(R1)(R2)—N wherein C is a chromophore; Q is selected from the group consisting of optionally substituted aliphatic, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R1 and R2 are independently selected from the group consisting of optionally substituted C1-8 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-8 alkyloxy, cycloalkyloxy, heterocycloalkyloxy, alkylsilyloxy and arylsilyloxy; and N is a glycosylamine or abasic moiety.
申请公布号 US2010216984(A1) 申请公布日期 2010.08.26
申请号 US20080600829 申请日期 2008.05.16
申请人 DHARMACON, INC. 发明人 DELANEY MICHAEL OREN
分类号 C07H19/00;C07D249/04;C07F7/12 主分类号 C07H19/00
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