| 发明名称 |
PDZ DOMAIN INTERACTIONS AND LIPID RAFTS |
| 摘要 |
Methods for modulating immune cell signaling are provided. In general such methods involve modulating an interaction between a PDZ protein and a PDZ ligand protein whose interaction affects the composition and/or distribution of lipid rafts in an immune cell. Modulators that enhance or inhibit such interactions are also disclosed, as well as methods of screening for such modulators.
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| 申请公布号 |
US2010215677(A1) |
申请公布日期 |
2010.08.26 |
| 申请号 |
US20100770682 |
申请日期 |
2010.04.29 |
| 申请人 |
ARBOR VITA CORPORATION;THE GENERAL HOSPITAL CORPORATION |
发明人 |
LU PETER S.;DIAZ-SARMIENTO CHAMORRO SOMOZA;SEED BRIAN;XAVIER RAMNIK;IRVING BRYAN ALLEN |
| 分类号 |
A61K39/00;A61P1/00;A61P3/10;A61P17/06;A61P19/02;A61P35/00;A61P35/02;A61P37/00;C07K2/00;C07K14/00;C12N5/07;G01N33/53;G01N33/564;G01N33/566 |
主分类号 |
A61K39/00 |
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