发明名称 |
1,2,4-OXADIOI.E DERIVATIVES WITH ACTIVITY AT THE METABOTROPIC CLUTAMATE RECEPTORS |
摘要 |
The present invention relates to new compounds of formula (I) wherein Y1 and Y2 selected from the group consisting of hydrogen, halogen atom; C1-4 alkyl, C1-4 alkoxy, cyano and trifluoromethyl group, Q is -CH- group or N; X1 and X2 are different and are independently selected from N and O; Z is -(CH2)n- group or S; n is 1 or 2; R is selected from the group consisting of optionally substituted C1-7 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 cyanoalkyl, C1-3 OC1-3 alkyl, C2-7 alkenyl, C2-7 alkynyl, C0-2(NR1R2)alkyl; an optionally substituted C3-7 cycloalkyl, aryl, heteroaryl or saturated heterocyclyl; R1 and R2 are independently selected from hydrogen, C1-7 alkyl or C1-6 alkanoyl group - and/or enentiomers and/or racemates and/or diastereomers and/or geometric isomers and/or pharmaceutically acceptable salts thereof formed with acids and bases, to the processes for producing said compounds, to pharmaceutical compositions containing said compounds and to their use in the prevention and/or treatment of mGluR5 receptor-mediated disorders. |
申请公布号 |
WO2007039781(A3) |
申请公布日期 |
2010.08.26 |
申请号 |
WO2006HU00087 |
申请日期 |
2006.10.05 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT.;GAL, KRISZTINA;WEBER, CSABA;WAGNER, GABOR, ANDRAS;HORVATH, ATTILA;NYEKI, GYOERGYNE;VASTAG, MONIKA;KESERUE, GYOERGY |
发明人 |
GAL, KRISZTINA;WEBER, CSABA;WAGNER, GABOR, ANDRAS;HORVATH, ATTILA;NYEKI, GYOERGYNE;VASTAG, MONIKA;KESERUE, GYOERGY |
分类号 |
C07D413/04;A61K31/4245;A61P25/00;C07D413/14 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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