Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue.
申请公布号
WO2010096470(A2)
申请公布日期
2010.08.26
申请号
WO2010US24458
申请日期
2010.02.17
申请人
GENENTECH, INC.;NIKOLAEV, ANATOLY;PINKSTON-GOSSE, JULIE;TESSIER-LAVIGNE, MARC
发明人
NIKOLAEV, ANATOLY;PINKSTON-GOSSE, JULIE;TESSIER-LAVIGNE, MARC