发明名称 |
POLYCYCLIC SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION |
摘要 |
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.
|
申请公布号 |
US2010216982(A1) |
申请公布日期 |
2010.08.26 |
申请号 |
US20100774566 |
申请日期 |
2010.05.05 |
申请人 |
ISIS PHARMACEUTIACLS, INC. |
发明人 |
ALLERSON CHARLES;BHAT BALKRISHEN;SWAYZE ERIC E.;PRAKASH THAZHA P. |
分类号 |
C07H21/02;C07H19/10;C07H19/20;C07H21/00;C07H21/04;C12N15/113;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|