ANTI-TUMOR, ANTI-BACTERIAL AND/OR ANTI-VIRAL APPLICATIONS OF CTLA4IG AND DERIVATIVES THEREOF.

摘要

The present invention relates to the use of CTLA4Ig or CTLA4Ig derivatives in the preparation of anti-tumor, anti-bacterial and/or anti-viral drugs. It was found by the inventor that CTLA4Ig or CTLA4Ig derivatives significantly enhanced the cytotoxicity of NK cells by increasing the expression of the activating receptors (such as NKG2D, NKp44 and the likes) on NK cell surface, thereby they could be used for the anti-tumor, anti-bacterial and/or anti-viral treatment.