发明名称 |
PERIPHERAL ADMINISTRATION OF PROTEINS INCLUDING TGF-.BETA. SUPERFAMILY MEMBERS FOR TREATMENT OF SYSTEMIC DISORDERS AND DISEASE |
摘要 |
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-ß superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent. |
申请公布号 |
CA2752157(A1) |
申请公布日期 |
2010.08.19 |
申请号 |
CA20102752157 |
申请日期 |
2010.02.12 |
申请人 |
STRYKER CORPORATION |
发明人 |
GOAD, MARY ELIZABETH PECQUET;HASKELL, MELISSA M.;SCHRIER, DENIS;WOOD, SUSAN A. |
分类号 |
A61K38/18;A61K9/00 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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