发明名称 |
COMBINATORIAL METHODS AND COMPOSITIONS FOR TREATMENT OF MELANOMA |
摘要 |
<p>The invention relates to combining targeted therapies with selected chemotherapeutics for the treatment of melanoma. The invention provides a method for inducing apoptosis in a melanoma tumor cell by reducing Akt3 activity, a method for inducing apoptosis in a melanoma tumor cell comprising contacting a melanoma tumor cell with an agent that reduces Akt3 activity to restore normal apoptotic sensitivity to a melanoma tumor cell, allowing a lower concentration of chemotherapeutic agents resulting in decreased toxicity to a patient. Also disclosed is a method for treating a melanoma comprising administering an agent that reduces Akt3 activity and an agent that reduces V599E B-Raf activity, thereby treating a melanoma tumor.</p> |
申请公布号 |
EP1744788(A4) |
申请公布日期 |
2010.08.18 |
申请号 |
EP20050733347 |
申请日期 |
2005.03.18 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
ROBERTSON, GAVIN, P.;KESTER, MARK;SANDIRASEGARANE, LAKSHMAN;SHARMA, ARATI |
分类号 |
C07H21/02;A61K31/00;A61K31/70;A61K48/00;C07H21/04;C12N15/113;C12N15/88;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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