发明名称 |
DIHYDROPYRAZOLOPYRIMIDINONDERIVATE |
摘要 |
<p>The invention relates to compounds of a general formula (I):
wherein Ar 1 is an optionally-substituted aryl or heteroaromatic group; R 1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R 2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R 3 is a hydrogen atom or a lower alkyl group; R 4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of -N(R 1k )R 1m ; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.</p> |
申请公布号 |
AT475662(T) |
申请公布日期 |
2010.08.15 |
申请号 |
AT20070742843T |
申请日期 |
2007.04.25 |
申请人 |
BANYU PHARMACEUTICAL CO., LTD. |
发明人 |
SAKAMOTO, TOSHIHIRO;SUNAMI, SATOSHI;YAMAMOTO, FUYUKI;NIIYAMA, KENJI;BAMBA, MAKOTO;TAKAHASHI, KEIJI;FURUYAMA, HIDETOMO;SAGARA, TAKESHI;OTSUKI, SACHIE;NISHIBATA, TOSHIHIDE;YOSHIZUMI, TAKASHI;HIRAI, HIROSHI |
分类号 |
C07D487/04;A61K31/519;A61P35/00;A61P43/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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