发明名称 |
POLYMORPHIC FORM OF GRANISETRON BASE, METHODS FOR OBTAINING IT AND FORMULATION CONTAINING IT |
摘要 |
Relates to a new polymorphic form of Granisetron base, Form I, to methods for obtaining thereof, to the method for obtaining Granisetron.HCl and its use for preparing pharmaceutical formulations. The Form I is characterized by the X-ray powder diffractogram shown in FIG. 1. Included in summarised form are the methods and solvents for obtaining the Form I: 1) Evaporation of hexane at atmospheric pressure; 2) Evaporation of acetone at atmospheric pressure; 3) Evaporation of toluene at atmospheric pressure; 4) Cooling of a saturated solution of diethyl ether to reflux temperature; 5) Evaporation of 2-propanol atmospheric pressure; 6) Evaporation of tetrahydrofuran at atmospheric pressure; and 7) Cooling of a saturated solution of acetonitrile to reflux temperature.
|
申请公布号 |
US2010204264(A1) |
申请公布日期 |
2010.08.12 |
申请号 |
US20070664153 |
申请日期 |
2007.12.20 |
申请人 |
INKE, S.A. |
发明人 |
DALMASES BARJOAN PERE;HERBERA ESPINAL REYES;ALVAREZ LARENA ANGEL MARIA |
分类号 |
A61K31/439;A61P1/08;C07D451/14 |
主分类号 |
A61K31/439 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|