SOLUBLE FLT CONSTRUCTS FOR TREATING CANCERS

摘要

Multimeric fusion proteins of an Ig-like domain of Flt-1 linked to a multimerization domain, either directly or using a linker moiety, are useful for treating certain tumors and pathological neovascularization. The fusion proteins can be produced recombinantly and readily purified using a simple two-column procedure. The columns employ a hydrophobic charge induction resin and a ceramic hydroxyapatite resin.