| 摘要 |
AN OSMOTIC PUMP SYSTEM INCLUDES A CAPSULE (404) HAVING AT LEAST ONE DELIVERY PORT (410), A MEMBRANE PLUG (412) RETAINED AT AN OPEN END (408) OF THE CAPSULE REMOTE FROM THE DELIVERY PORT (410), THE MEMBRANE PLUG (412) PROVIDING A FLUID-PERMEABLE BARRIER BETWEEN AN INTERIOR AND AN EXTERIOR OF THE CAPSULE, AND A REMOVABLE IMBIBITION RATE REDUCER ATTACHABLE TO THE CAPSULE. THE IMBIBITION RATE REDUCER COMPRISES ONE OR MORE FLOW CONTROLLERS SELECTED FROM THE GROUP CONSISTING OF AN ORIFICE HAVING A SELECTED SIZE SMALLER THAN A SURFACE AREA OF THE MEMBRANE PLUG (412) AND A MEMBRANE HAVING A SELECTED THICKNESS, SURFACE AREA, RADIAL COMPRESSION, AND PERMEABILITY. THE IMBIBITION RATE REDUCER ALLOWS CUSTOMIZABLE DELIVERY OF MEDICAMENTS. (FIGURE 4A)
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