发明名称 |
Modified retinoid compounds and their uses |
摘要 |
A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group and the resulting modified retinoids are described. The method comprises the step of esterifying the carboxyl group of the retinoid with a highly sterically hindered compound, which is preferably a secondary or tertiary alcohol. The resulting retinoid esters are rendered much less toxic than the starting or parent retinoid. This process provides a retinoid ester analog of reduced toxicity so that it may be administered orally with minimal side effects and with a much greater therapeutic window. The modified retinoid compounds are useful in the treatment and prophylaxis of all diseases and disorders where retinoid compounds have been shown effective.
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申请公布号 |
US7763599(B2) |
申请公布日期 |
2010.07.27 |
申请号 |
US20080061247 |
申请日期 |
2008.04.02 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA HECTOR F.;CLAGETT-DAME MARGARET;GOWLUGARI SUMITHRA |
分类号 |
A61K31/59;A61K8/67;A61K31/203;A61K31/215;A61P17/10;A61P35/00;A61Q19/00;A61Q19/08;C07C69/76;C07C401/00;C07C403/20;C07J9/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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