发明名称 Prodrugs of HIV replication inhibiting pyrimidines
摘要 The present invention concerns compounds of formula (A1)(A2)N—R1 (I), the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(═O)—R8; —S(═O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formula
申请公布号 US7763631(B2) 申请公布日期 2010.07.27
申请号 US20050225839 申请日期 2005.09.13
申请人 JANSSEN PHARMACEUTICA NV 发明人 KUKLA MICHAEL JOSEPH;LUDOVICI DONALD WILLIAM;KAVASH ROBERT WILLIAM;DE CORTE BART LIEVEN DANIEL;HEERES JAN;JANSSEN PAUL ADRIAAN JAN;KOYMANS LUCIEN MARIA HENRICUS;DE JONGE MARC RENE;VAN AKEN KOEN JEANNE ALFONS;KRIEF ALAIN
分类号 C07D239/47;C07D401/12;A61K31/444;A61K31/505;A61K31/506;A61K31/5377;A61K45/00;A61K47/48;A61P31/18;A61P43/00;C07D239/46;C07D239/48;C07D403/12 主分类号 C07D239/47
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