MODELS OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND METHODS OF USE THEREOF
摘要
The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.
申请公布号
WO2010062604(A3)
申请公布日期
2010.07.22
申请号
WO2009US62228
申请日期
2009.10.27
申请人
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;SCHWARZ, HANS-PETER;MUCHITSCH, EVA-MARIA;TURECEK, PETER
发明人
SCHWARZ, HANS-PETER;MUCHITSCH, EVA-MARIA;TURECEK, PETER