发明名称 |
SELF-ASSEMBLING MICELLE-LIKE NANOPARTICLES FOR SYSTEMIC GENE DELIVERY |
摘要 |
<p>Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA-containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid/PEG-lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor.</p> |
申请公布号 |
EP2207903(A1) |
申请公布日期 |
2010.07.21 |
申请号 |
EP20080847078 |
申请日期 |
2008.11.10 |
申请人 |
NORTHEASTERN UNIVERSITY |
发明人 |
KO, YOUNG, TAG;KALE, AMIT;TORCHILIN, VLADIMIR, P. |
分类号 |
C12Q1/68;G01N33/551;G01N33/553 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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