| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention describes novel 1,2,3-triazole derivatives of general formula: , where X denotes O or N-OH; R1 is hydrogen, fluorine, chlorine, bromine, phenyl or C1-4-alkyl, unsubstituted or substituted 1-3 times with fluorine, chlorine and bromine; R2 - R5 hydrogen; pharmaceutically acceptable salts and stereoisomers thereof and a pharmaceutical composition containing the said compounds. ^ EFFECT: obtaining compounds which can be used as oestrogen receptor selective modulators for treating or preventing different conditions related to oestrogen function, including: bone loss, bone fracture, osteoporosis, metastatic bone disease, Piaget's disease, periodontal disease etc. ^ 5 cl, 7 ex |
