发明名称 |
ANTI-FXI ANTIBODIES AND METHODS OF USE |
摘要 |
Disclosed herein are monoclonal antibodies specific for factor XI (fXI) that prevent activation of fXI by factor XIIa (fXIIa). The monoclonal antibodies are universal fXI antibodies, capable of binding all mammalian species tested. The anti- fXI monoclonal antibodies prolong clotting time in mammalian plasmas. Moreover, administration of the fXI monoclonal antibodies disclosed herein results in inhibition of thrombosis without altering hemostasis in animal models of thrombosis. Thus, provided herein are monoclonal antibodies specific for fXI that block activation of fXI by fXIIa, compositions and immunoconjugates comprising such antibodies and their methods of use. |
申请公布号 |
WO2010080623(A2) |
申请公布日期 |
2010.07.15 |
申请号 |
WO2009US68768 |
申请日期 |
2009.12.18 |
申请人 |
OREGON HEALTH & SCIENCE UNIVERSITY;VANDERBILT UNIVERSITY;GRUBER, ANDRAS;TUCKER, ERIK, I.;GAILANI, DAVID |
发明人 |
GRUBER, ANDRAS;TUCKER, ERIK, I.;GAILANI, DAVID |
分类号 |
C07K16/36;A61K39/395;A61P7/02;C12N15/13 |
主分类号 |
C07K16/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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