发明名称 |
ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15 |
摘要 |
To provide a method of detecting abnormal bone metabolism by using a gene strongly expressed in an osteoclast; a method of screening a compound having a therapeutic and/or preventive effect on abnormal bone metabolism; and a pharmaceutical composition for treating and/or preventing abnormal bone metabolism. [Means for Resolution] Provision of a method of detecting abnormal bone metabolism by using the expression of human Siglec-15 gene as an index; a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation; and the like. |
申请公布号 |
EP2206727(A1) |
申请公布日期 |
2010.07.14 |
申请号 |
EP20080838427 |
申请日期 |
2008.10.08 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
HIRUMA YOSHIHARU;TSUDA EISUKE |
分类号 |
C07K16/28;A61K31/122;A61K31/352;A61K31/593;A61K31/663;A61K39/395;A61K45/06;C07K16/18 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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