摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of obtaining optically active amlodipine trough optical separation of (R,S)-amlodipines where (R,S)-amlodipine reacts with optically active O,O'-dibenzoyl- tartaric acid in an isopropanol solvent to obtain optically active salt of amlodipine-hemi-dibenzoyl-L-tartrate or its solvate, and the optically active salt of amlodipine-hemi-dibenzoyl-L-tartrate or its solvate is treated with a base to obtain optically active amlodipine. The invention also relates to (R)-(+)-amlodipine-hemi-dibenzoyl-L-tartrate, (S)-(-)-amlodipine-hemi-dibenzoyl-D-tartrate, (S)-(-)-amlodipine-hemi-dibenzoyl-L-tatrate, (R)-(+)- amlodipine-hemi-dibenzoyl-D-tatrate or solvates thereof. ^ EFFECT: obtaining enantiomerically pure amlodipine isomers with activity calcium channel blocker properties. ^ 23 cl, 18 ex, 1 tbl |