发明名称 POLYMORPHIC FORM OF 5-CHLORO-N-{[(5S)-2-OXO-3-[4-(3-OXOMORPHOLIN-4-YL)PHENYL]OXA-ZOLIDIN-5-YL]-METHYL}THIOPHENE-2-CARBOXAMIDE
摘要 A polymorphic form of rivaroxaban, 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxa-zolidin-5-yl]- methyl}thiophene-2-carboxamide (termed form APO-A), processes for the preparation thereof, and compositions and formulations comprising form APO-A are provided. Also provided are compositions comprising a crystalline form of rivaroxaban and solvents selected from C3 to C6 ketones, C3 to C4 amides and mixtures thereof.
申请公布号 CA2748853(A1) 申请公布日期 2010.07.08
申请号 CA20092748853 申请日期 2009.12.31
申请人 APOTEX PHARMACHEM INC. 发明人 BODHURI, PRABHUDAS;WEERATUNGA, GAMINI
分类号 C07D413/14;A61K31/5377 主分类号 C07D413/14
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