发明名称 |
IgM Production by Transformed Cell and Method of Quantifying the Same |
摘要 |
IgM can be obtained in the form of a pentamer by placing the genes encoding the H, L, and J chains on the same vector to transform appropriate host cells. The gene encoding the J chain may be introduced by co-transfection. When no J chain is expressed, the IgM is produced as a hexamer. The transformants obtained according to the present invention achieve a high yield of IgM. The present invention also provides methods which enable separation and quantification of polymeric IgM. |
申请公布号 |
US2010172899(A1) |
申请公布日期 |
2010.07.08 |
申请号 |
US20100727162 |
申请日期 |
2010.03.18 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IRIE REIKO;TSUNODA HIROYUKI;IGAWA TOMOYUKI;SEKIMORI YASUO;TSUCHIYA MASAYUKI |
分类号 |
A61K39/395;C07K14/47;C07K16/00;C07K16/30;C07K17/10;C12N15/13;G01N33/68 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|