发明名称 |
DUAL DRUG DOSAGE FORMS WITH IMPROVED SEPARATION OF DRUGS |
摘要 |
Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing full access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion. |
申请公布号 |
EP1646368(A4) |
申请公布日期 |
2010.07.07 |
申请号 |
EP20040778191 |
申请日期 |
2004.07.13 |
申请人 |
DEPOMED, INC. |
发明人 |
LIM, JONG;SHELL, JOHN, N.;LOUIE-HELM, JENNY |
分类号 |
A61K9/22;A61K9/20;A61K9/24;A61K31/00 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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