| 摘要 |
[Object] The aim of the present invention is to develop a novel immunoglobulin binding polypeptide, the loss and formation of whose native three dimensional structure can be controlled under the conditions where unwanted effects such as damages, loss of functions or unintended functions do not occur to immunoglobulin (pH 5-9, lower than 60° C.), and use thereof as a ligand coupled to an affinity chromatography support. [Means for solving the problems] A mutant of the polypeptide set forth in SEQ ID NO 1 or SEQ ID NO 2, wherein immunoglobulin binding properties can be altered by changing temperature under the conditions of pH 5-9, below 60° C., and the use thereof.
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