NOVEL PYRAZOLODIAZEPINE COMPOUNDS AS A TRANSGLUTAMINASE INHIBITOR, THE PREPARATION METHOD THEREOF AND A COMPOSITION CONTAINING THE SAME
摘要
The present invention relates to the novel pyrazolodiazepine compounds which potently inhibit the activity of transglutaminase in a dose dependent manner. Accordingly, it has been confirmed that the inventive compounds show potent inhibiting effect on the hyper- activated transglutaminase when the transglutaminase is over-expressed. Therefore the compounds can be useful in treating or preventing the disease caused by increased activation of transglutaminase.
申请公布号
WO2010074480(A2)
申请公布日期
2010.07.01
申请号
WO2009KR07664
申请日期
2009.12.22
申请人
NATIONAL CANCER CENTER;ANYGEN CO., LTD.;KIM, YOUNG-CHUL;LEE, JU-YEON;KIM, SOO YOUL;LEE, BYUNG IL
发明人
KIM, YOUNG-CHUL;LEE, JU-YEON;KIM, SOO YOUL;LEE, BYUNG IL