发明名称 |
Surface chemical modification of optical elements for the spectroscopic detection of molecules and organic components |
摘要 |
The invention relates to a device suitable for the investigation of ligand-receptor interactions, in particular for the investigation of an analyte target interaction such as biological and chemical molecules and organic components and their interaction with surfaces, consisting of an attenuated total internal reflection element, transparent in the infra-red and of which at least one surface is chemically activated and covalently grafted with an organic molecule able to immobilize the receptor. The invention further relates to the use of said device and a method for the construction of said device comprising the steps of:
- surface activation of at least one surface of an attenuated total internal reflection element,
- surface grafting with an organic molecule of the activated surface obtained in the previous step, and
- coupling a receptor via covalent fixation on the organic molecule.
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申请公布号 |
EP2202521(A1) |
申请公布日期 |
2010.06.30 |
申请号 |
EP20100154491 |
申请日期 |
2002.01.15 |
申请人 |
UNIVERSITE CATHOLIQUE DE LOUVAIN;UNIVERSITE LIBRE DE BRUXELLES;UNIVERSITE DE MONS-HAINAUT |
发明人 |
MARCHAND-BRYNAERT, JACQUELINE ANNE-MARIE GERMAINE;GOORMAGHTIGH, ERIK ROBERT MARCEL CHARLES;HOMBLE, FABRICE ROLAND;VOUE, MICHEL PIERRE ERNEST;DE CONINCK, JOEL JOSEPH FLORENT |
分类号 |
G01N33/543;G01N21/55 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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